People have mentioned Directory Opus, I use Directory Opus, which uses hotkeys as well as numerous other programs that do and it was because of all the Hotkeys conflicting that I used Macro Express Pro cutting out as many Hotkeys from other programs as I could, but with the dramatic slowdowns MEP causes I am now using Autohotkey and Direct Access only opening MEP and closing it as soon as finished,
Could the problem be Hotkeys? As you suggest
It is stupid that I am not using MEP as I should because of a bug in it, I just wish I could start using it again properly as it would save me so much time.